/* ============================================================
   RENAGENBIO - Design System & Styles
   Palette: Deep navy/slate primary, cool teal accent, clean whites
   Fonts: Instrument Serif (display) + DM Sans (body)
   ============================================================ */

:root,
[data-theme='light'] {
  --color-bg: #f8f9fb;
  --color-surface: #ffffff;
  --color-surface-2: #f2f4f8;
  --color-surface-alt: #eef1f7;
  --color-border: #d8dce6;
  --color-divider: #e4e7ef;
  --color-text: #111827;
  --color-text-muted: #6b7280;
  --color-text-faint: #9ca3af;
  --color-text-inverse: #f9fafb;
  --color-primary: #0d5c6e;
  --color-primary-hover: #0a4a59;
  --color-primary-active: #073844;
  --color-primary-light: #e0f0f4;
  --color-accent: #0ea5b8;
  --color-accent-light: #d0f0f5;
  --color-dark-bg: #0b1e2d;
  --color-dark-surface: #132435;
  --color-dark-text: #e8edf3;
  --color-dark-text-muted: #8fa4b8;
  --shadow-sm: 0 1px 3px rgba(11,30,45,0.07);
  --shadow-md: 0 4px 16px rgba(11,30,45,0.10);
  --shadow-lg: 0 12px 40px rgba(11,30,45,0.14);
  --radius-sm: 0.375rem;
  --radius-md: 0.625rem;
  --radius-lg: 1rem;
  --radius-xl: 1.5rem;
  --radius-full: 9999px;
  --transition: 180ms cubic-bezier(0.16, 1, 0.3, 1);
  --content-default: 1100px;
  --font-display: 'Instrument Serif', Georgia, serif;
  --font-body: 'DM Sans', 'Helvetica Neue', sans-serif;
}

[data-theme='dark'] {
  --color-bg: #0d1520;
  --color-surface: #131e2e;
  --color-surface-2: #192438;
  --color-surface-alt: #1c2940;
  --color-border: #253348;
  --color-divider: #1f2e42;
  --color-text: #dce5f0;
  --color-text-muted: #7a90a8;
  --color-text-faint: #4a6078;
  --color-text-inverse: #0d1520;
  --color-primary: #2db8cc;
  --color-primary-hover: #1fa8ba;
  --color-primary-active: #1594a4;
  --color-primary-light: #0e2a35;
  --color-accent: #38c8dc;
  --color-accent-light: #0d2830;
  --shadow-sm: 0 1px 3px rgba(0,0,0,0.25);
  --shadow-md: 0 4px 16px rgba(0,0,0,0.35);
  --shadow-lg: 0 12px 40px rgba(0,0,0,0.45);
}

*, *::before, *::after { box-sizing: border-box; margin: 0; padding: 0; }
html { -webkit-font-smoothing: antialiased; -moz-osx-font-smoothing: grayscale; text-rendering: optimizeLegibility; scroll-behavior: smooth; scroll-padding-top: var(--space-16, 4rem); }
body { min-height: 100dvh; line-height: 1.6; font-family: var(--font-body); font-size: clamp(1rem,.95rem + .25vw,1.125rem); color: var(--color-text); background-color: var(--color-bg); }
img, picture, video, canvas, svg { display: block; max-width: 100%; height: auto; }
ul[role='list'], ol[role='list'] { list-style: none; }
input, button, textarea, select { font: inherit; color: inherit; }
h1, h2, h3, h4, h5, h6 { text-wrap: balance; line-height: 1.15; }
p, li, figcaption { text-wrap: pretty; max-width: 72ch; }
::selection { background: var(--color-primary-light); color: var(--color-text); }
:focus-visible { outline: 2px solid var(--color-primary); outline-offset: 3px; border-radius: var(--radius-sm); }
sup { font-size: .65em; vertical-align: super; }
@media (prefers-reduced-motion: reduce) { *, *::before, *::after { animation-duration: 0.01ms !important; transition-duration: 0.01ms !important; } }

.container { width: 100%; max-width: var(--content-default); margin-inline: auto; padding-inline: clamp(1.25rem,5vw,3rem); }

.btn { display: inline-flex; align-items: center; gap: .5rem; padding: .65rem 1.4rem; border-radius: var(--radius-md); font-family: var(--font-body); font-size: clamp(.875rem,.8rem + .35vw,1rem); font-weight: 500; letter-spacing: .01em; text-decoration: none; cursor: pointer; border: none; transition: background var(--transition), color var(--transition), box-shadow var(--transition), transform var(--transition); white-space: nowrap; }
.btn:hover { transform: translateY(-1px); }
.btn:active { transform: translateY(0); }
.btn--primary { background: var(--color-primary); color: #fff; box-shadow: var(--shadow-sm); }
.btn--primary:hover { background: var(--color-primary-hover); box-shadow: var(--shadow-md); }
.btn--ghost { background: transparent; color: var(--color-text); border: 1.5px solid var(--color-border); }
.btn--ghost:hover { background: var(--color-surface-alt); border-color: var(--color-primary); color: var(--color-primary); }
.btn--white { background: #fff; color: var(--color-dark-bg); font-weight: 600; }
.btn--white:hover { background: #e8f4f7; }
.btn--lg { padding: .85rem 1.8rem; font-size: clamp(1rem,.95rem + .25vw,1.125rem); }
.btn--full { width: 100%; justify-content: center; }

.header { position: sticky; top: 0; z-index: 100; background: color-mix(in srgb, var(--color-bg) 92%, transparent); backdrop-filter: blur(14px); -webkit-backdrop-filter: blur(14px); border-bottom: 1px solid transparent; transition: box-shadow var(--transition), border-color var(--transition), transform .3s cubic-bezier(.16,1,.3,1); }
.header--scrolled { box-shadow: var(--shadow-sm); border-bottom-color: var(--color-divider); }
.header--hidden { transform: translateY(-100%); }
.header__inner { display: flex; align-items: center; gap: 2rem; height: 68px; }
.logo { display: flex; align-items: center; gap: .75rem; text-decoration: none; color: var(--color-text); font-family: var(--font-display); font-size: 1.25rem; flex-shrink: 0; }
.logo--small { font-size: 1.1rem; }
.logo svg { color: var(--color-primary); }
.nav { margin-left: auto; }
.nav__list { display: flex; gap: .25rem; list-style: none; }
.nav__link { display: block; padding: .5rem .75rem; font-size: clamp(.875rem,.8rem + .35vw,1rem); color: var(--color-text-muted); text-decoration: none; border-radius: var(--radius-sm); transition: color var(--transition), background var(--transition); }
.nav__link:hover { color: var(--color-text); background: var(--color-surface-alt); }
.header__actions { display: flex; align-items: center; gap: .75rem; }
.theme-toggle { display: flex; align-items: center; justify-content: center; width: 36px; height: 36px; border-radius: var(--radius-full); color: var(--color-text-muted); cursor: pointer; transition: background var(--transition), color var(--transition); border: none; background: none; }
.theme-toggle:hover { background: var(--color-surface-alt); color: var(--color-text); }
.nav-toggle { display: none; flex-direction: column; gap: 5px; width: 36px; height: 36px; align-items: center; justify-content: center; border: none; background: none; cursor: pointer; margin-left: auto; }
.nav-toggle span { display: block; width: 22px; height: 2px; background: var(--color-text); border-radius: 2px; transition: transform .3s, opacity .3s; }
.nav-toggle--open span:nth-child(1) { transform: translateY(7px) rotate(45deg); }
.nav-toggle--open span:nth-child(2) { opacity: 0; }
.nav-toggle--open span:nth-child(3) { transform: translateY(-7px) rotate(-45deg); }

.hero { padding-top: clamp(4rem,10vw,8rem); padding-bottom: 0; overflow: hidden; }
.hero__inner { display: grid; grid-template-columns: 1fr 1fr; gap: 4rem; align-items: center; padding-bottom: clamp(4rem,8vw,6rem); }
.hero__tag { display: inline-block; font-size: clamp(.75rem,.7rem + .25vw,.875rem); font-weight: 600; letter-spacing: .08em; text-transform: uppercase; color: var(--color-primary); background: var(--color-primary-light); padding: .25rem .75rem; border-radius: var(--radius-full); margin-bottom: 1.5rem; }
.hero__heading { font-family: var(--font-display); font-size: clamp(2.75rem,1rem + 5.5vw,5.5rem); font-weight: 400; color: var(--color-text); line-height: 1.05; margin-bottom: 1.5rem; }
.hero__heading em { font-style: italic; color: var(--color-primary); }
.hero__lead { font-size: clamp(1.125rem,1rem + .75vw,1.5rem); color: var(--color-text-muted); line-height: 1.65; margin-bottom: 2.5rem; max-width: 52ch; }
.hero__ctas { display: flex; gap: .75rem; flex-wrap: wrap; }

.hero__visual { display: flex; align-items: center; justify-content: center; }
.hero__diagram { position: relative; width: 320px; height: 320px; }
.cell-diagram { position: relative; width: 100%; height: 100%; }
.cell-ring { position: absolute; inset: 0; border-radius: 50%; border: 1.5px solid var(--color-primary); animation: pulse-ring 3s ease-in-out infinite; }
.cell-ring--1 { opacity: .15; animation-delay: 0s; }
.cell-ring--2 { inset: 15%; opacity: .25; animation-delay: .6s; }
.cell-ring--3 { inset: 30%; opacity: .4; animation-delay: 1.2s; }
.cell-core { position: absolute; inset: 42%; display: flex; align-items: center; justify-content: center; color: var(--color-primary); }
@keyframes pulse-ring { 0%,100% { transform: scale(1); opacity: .15; } 50% { transform: scale(1.03); opacity: .3; } }
.cell-ring--2 { animation-name: pulse-ring-2; }
@keyframes pulse-ring-2 { 0%,100% { transform: scale(1); opacity: .25; } 50% { transform: scale(1.04); opacity: .45; } }
.cell-ring--3 { animation-name: pulse-ring-3; }
@keyframes pulse-ring-3 { 0%,100% { transform: scale(1); opacity: .4; } 50% { transform: scale(1.06); opacity: .65; } }
.cell-label { position: absolute; font-size: clamp(.75rem,.7rem + .25vw,.875rem); font-weight: 500; color: var(--color-text-muted); white-space: nowrap; }
.cell-label--1 { top: 5%; left: 50%; transform: translateX(-50%); }
.cell-label--2 { top: 50%; right: -2%; transform: translateY(-50%); }
.cell-label--3 { bottom: 5%; left: 50%; transform: translateX(-50%); }
.cell-label--4 { top: 50%; left: -8%; transform: translateY(-50%); }

.hero__stats { background: var(--color-surface); border-top: 1px solid var(--color-divider); padding-block: 2rem; }
.stats-row { display: flex; align-items: center; justify-content: space-between; gap: 1.5rem; flex-wrap: wrap; }
.stat { text-align: center; flex: 1; min-width: 140px; }
.stat__number { display: block; font-family: var(--font-display); font-size: clamp(1.5rem,1.2rem + 1.25vw,2.25rem); color: var(--color-primary); line-height: 1.1; }
.stat__label { display: block; font-size: clamp(.75rem,.7rem + .25vw,.875rem); color: var(--color-text-muted); margin-top: .25rem; max-width: 18ch; margin-inline: auto; }
.stat__divider { width: 1px; height: 48px; background: var(--color-divider); flex-shrink: 0; }

.section { padding-block: clamp(4rem,8vw,6rem); }
.section--alt { background: var(--color-surface); }
.section--dark { background: var(--color-dark-bg); color: var(--color-dark-text); }
.section-header { text-align: center; max-width: 680px; margin-inline: auto; margin-bottom: clamp(3rem,5vw,4rem); }
.section-tag { display: inline-block; font-size: clamp(.75rem,.7rem + .25vw,.875rem); font-weight: 600; letter-spacing: .1em; text-transform: uppercase; color: var(--color-primary); margin-bottom: 1rem; }
.section-tag--light { color: var(--color-accent); }
.section-title { font-family: var(--font-display); font-size: clamp(2rem,1.2rem + 2.5vw,3.5rem); font-weight: 400; color: var(--color-text); margin-bottom: 1.25rem; line-height: 1.2; }
.section-title--light { color: var(--color-dark-text); }
.section-title em { font-style: italic; color: var(--color-primary); }
.section-subtitle { font-size: clamp(1rem,.95rem + .25vw,1.125rem); color: var(--color-text-muted); line-height: 1.7; max-width: 60ch; margin-inline: auto; }

.science-grid { display: grid; grid-template-columns: repeat(3,1fr); gap: 1.25rem; margin-bottom: 3rem; }
.science-card { background: var(--color-bg); border: 1px solid var(--color-border); border-radius: var(--radius-lg); padding: 2rem; transition: box-shadow var(--transition), border-color var(--transition); }
.science-card:hover { box-shadow: var(--shadow-md); border-color: var(--color-primary); }
.science-card__icon { width: 52px; height: 52px; background: var(--color-primary-light); border-radius: var(--radius-md); display: flex; align-items: center; justify-content: center; color: var(--color-primary); margin-bottom: 1.25rem; }
.science-card__title { font-size: clamp(1.125rem,1rem + .75vw,1.5rem); font-weight: 600; margin-bottom: .75rem; color: var(--color-text); }
.science-card__text { font-size: clamp(.875rem,.8rem + .35vw,1rem); color: var(--color-text-muted); line-height: 1.65; }

.research-bar { display: flex; flex-direction: column; align-items: flex-start; gap: 1rem; padding: 1.25rem 1.5rem; background: var(--color-primary-light); border-radius: var(--radius-lg); border: 1px solid var(--color-accent-light); overflow: hidden; }
.research-bar__text { font-size: clamp(.7rem,.65rem + .25vw,.8125rem); font-weight: 600; color: var(--color-primary); text-transform: uppercase; letter-spacing: .06em; max-width: 100%; word-wrap: break-word; overflow-wrap: break-word; }
.research-bar__logos { display: flex; gap: .625rem; flex-wrap: wrap; align-items: stretch; width: 100%; }
.research-inst { font-size: clamp(.75rem,.7rem + .25vw,.875rem); color: var(--color-text-muted); padding: .5rem .875rem; background: var(--color-surface); border-radius: var(--radius-md); border: 1px solid var(--color-border); white-space: normal; overflow-wrap: break-word; word-wrap: break-word; max-width: 100%; box-sizing: border-box; line-height: 1.4; display: inline-block; }

.pipeline-table-wrap { overflow-x: auto; border-radius: var(--radius-lg); border: 1px solid var(--color-border); box-shadow: var(--shadow-sm); }
.pipeline-table { width: 100%; border-collapse: collapse; font-size: clamp(.875rem,.8rem + .35vw,1rem); background: var(--color-surface); }
.pipeline-table thead { background: var(--color-surface-2); border-bottom: 1px solid var(--color-border); }
.pipeline-table th { padding: 1rem 1.5rem; text-align: left; font-weight: 600; font-size: clamp(.75rem,.7rem + .25vw,.875rem); text-transform: uppercase; letter-spacing: .07em; color: var(--color-text-muted); }
.pipeline-table td { padding: 1rem 1.5rem; border-bottom: 1px solid var(--color-divider); color: var(--color-text); vertical-align: middle; }
.pipeline-table tr:last-child td { border-bottom: none; }
.pipeline-row--priority { background: color-mix(in srgb, var(--color-primary-light) 60%, transparent); }
.badge { display: inline-flex; align-items: center; padding: .2rem .65rem; border-radius: var(--radius-full); font-size: clamp(.75rem,.7rem + .25vw,.875rem); font-weight: 600; }
.badge--pre { background: #dcfce7; color: #166534; }
.badge--lead { background: var(--color-primary-light); color: var(--color-primary); }
[data-theme='dark'] .badge--pre { background: #14532d; color: #86efac; }

.model-columns { display: grid; grid-template-columns: 1fr 1fr; gap: 1.5rem; margin-bottom: 2rem; }
.model-col { border-radius: var(--radius-lg); border: 1px solid var(--color-border); overflow: hidden; background: var(--color-surface); }
.model-col__header { padding: 1rem 1.5rem; font-size: clamp(.75rem,.7rem + .25vw,.875rem); font-weight: 700; text-transform: uppercase; letter-spacing: .08em; }
.model-col__header--you { background: var(--color-surface-alt); color: var(--color-text-muted); }
.model-col__header--us { background: var(--color-primary); color: #fff; }
.model-list { padding: 1.25rem 1.5rem; display: flex; flex-direction: column; gap: .75rem; }
.model-list__item { display: flex; align-items: flex-start; gap: .75rem; font-size: clamp(.875rem,.8rem + .35vw,1rem); color: var(--color-text); line-height: 1.5; max-width: none; }
.model-list__icon { flex-shrink: 0; margin-top: 2px; color: var(--color-text-muted); }
.model-list__icon--accent { color: var(--color-primary); }
.model-note { display: flex; gap: 1rem; align-items: flex-start; background: var(--color-surface-alt); border-radius: var(--radius-md); border: 1px solid var(--color-border); padding: 1.25rem 1.5rem; color: var(--color-text-muted); font-size: clamp(.875rem,.8rem + .35vw,1rem); line-height: 1.65; }
.model-note svg { flex-shrink: 0; margin-top: 2px; color: var(--color-primary); }
.model-note p { max-width: none; }

.process-steps { display: flex; flex-direction: column; gap: 0; max-width: 740px; margin-inline: auto; }
.process-step { display: grid; grid-template-columns: 64px 1fr; gap: 1.5rem; align-items: flex-start; padding: 1.5rem 0; }
.process-step__number { font-family: var(--font-display); font-size: clamp(1.5rem,1.2rem + 1.25vw,2.25rem); color: var(--color-primary); font-style: italic; line-height: 1; padding-top: 4px; }
.process-step__content { padding-bottom: .5rem; }
.process-step__title { font-size: clamp(1.125rem,1rem + .75vw,1.5rem); font-weight: 600; color: var(--color-text); margin-bottom: .5rem; }
.process-step__text { font-size: clamp(.875rem,.8rem + .35vw,1rem); color: var(--color-text-muted); line-height: 1.7; }
.process-step__time { display: inline-block; margin-top: .75rem; font-size: clamp(.75rem,.7rem + .25vw,.875rem); font-weight: 600; color: var(--color-primary); background: var(--color-primary-light); padding: .2rem .65rem; border-radius: var(--radius-full); }
.process-connector { width: 1px; height: 1.5rem; background: var(--color-border); margin-left: 31px; }

.why-now-grid { display: grid; grid-template-columns: 1fr 1fr; gap: clamp(3rem,6vw,5rem); align-items: center; }
.why-now__body { font-size: clamp(1rem,.95rem + .25vw,1.125rem); color: var(--color-dark-text-muted); line-height: 1.75; margin-bottom: 1.25rem; max-width: 50ch; }
.why-now__stats { display: grid; grid-template-columns: 1fr 1fr; gap: 1.25rem; }
.why-stat { background: var(--color-dark-surface); border: 1px solid rgba(255,255,255,.06); border-radius: var(--radius-lg); padding: 1.5rem; }
.why-stat__number { font-family: var(--font-display); font-size: clamp(2rem,1.2rem + 2.5vw,3.5rem); color: var(--color-accent); line-height: 1.05; margin-bottom: .5rem; }
.why-stat__label { font-size: clamp(.75rem,.7rem + .25vw,.875rem); color: var(--color-dark-text-muted); line-height: 1.55; max-width: 22ch; }

.contact-wrapper { display: grid; grid-template-columns: 1fr 1fr; gap: clamp(3rem,6vw,5rem); align-items: flex-start; }
.contact__body { font-size: clamp(1rem,.95rem + .25vw,1.125rem); color: var(--color-text-muted); line-height: 1.7; margin-bottom: 2rem; }
.contact__criteria { background: var(--color-surface-alt); border-radius: var(--radius-md); border: 1px solid var(--color-border); padding: 1.5rem; }
.contact__criteria-title { font-size: clamp(.875rem,.8rem + .35vw,1rem); font-weight: 600; color: var(--color-text); margin-bottom: .75rem; max-width: none; }
.contact__criteria ul { display: flex; flex-direction: column; gap: .5rem; }
.contact__criteria li { font-size: clamp(.875rem,.8rem + .35vw,1rem); color: var(--color-text-muted); padding-left: 1rem; position: relative; max-width: none; }
.contact__criteria li::before { content: '·'; position: absolute; left: 0; color: var(--color-primary); }
.contact-form { background: var(--color-surface); border: 1px solid var(--color-border); border-radius: var(--radius-xl); padding: 2rem; box-shadow: var(--shadow-md); display: flex; flex-direction: column; gap: 1.25rem; }
.form-row { display: flex; flex-direction: column; gap: .5rem; }
.form-label { font-size: clamp(.875rem,.8rem + .35vw,1rem); font-weight: 500; color: var(--color-text); }
.form-input { width: 100%; padding: .7rem 1rem; background: var(--color-bg); border: 1.5px solid var(--color-border); border-radius: var(--radius-md); font-size: clamp(.875rem,.8rem + .35vw,1rem); color: var(--color-text); transition: border-color var(--transition), box-shadow var(--transition); appearance: none; }
.form-input:focus { outline: none; border-color: var(--color-primary); box-shadow: 0 0 0 3px var(--color-primary-light); }
.form-input::placeholder { color: var(--color-text-faint); }
.form-textarea { resize: vertical; min-height: 100px; }
.form-disclaimer { font-size: clamp(.75rem,.7rem + .25vw,.875rem); color: var(--color-text-faint); text-align: center; line-height: 1.5; max-width: none; }

.footer { background: var(--color-surface); border-top: 1px solid var(--color-divider); padding-block: 3rem; }
.footer__inner { display: flex; flex-direction: column; gap: 1.5rem; align-items: flex-start; }
.footer__brand { display: flex; flex-direction: column; gap: .5rem; }
.footer__tagline { font-size: clamp(.875rem,.8rem + .35vw,1rem); color: var(--color-text-muted); }
.footer__nav { display: flex; gap: 1.25rem; flex-wrap: wrap; }
.footer__link { font-size: clamp(.875rem,.8rem + .35vw,1rem); color: var(--color-text-muted); text-decoration: none; transition: color var(--transition); }
.footer__link:hover { color: var(--color-primary); }
.footer__legal { font-size: clamp(.75rem,.7rem + .25vw,.875rem); color: var(--color-text-faint); line-height: 1.6; max-width: 70ch; }

.reveal { opacity: 0; transform: translateY(18px); transition: opacity .55s cubic-bezier(.16,1,.3,1), transform .55s cubic-bezier(.16,1,.3,1); }
.reveal.revealed { opacity: 1; transform: translateY(0); }

@media (max-width:900px) {
  .hero__inner { grid-template-columns: 1fr; }
  .hero__visual { display: none; }
  .science-grid { grid-template-columns: repeat(2,1fr); }
  .model-columns { grid-template-columns: 1fr; }
  .why-now-grid { grid-template-columns: 1fr; }
  .contact-wrapper { grid-template-columns: 1fr; }
  .nav { display: none; position: absolute; top: 68px; left: 0; right: 0; background: var(--color-surface); border-bottom: 1px solid var(--color-border); padding: 1rem; box-shadow: var(--shadow-md); }
  .nav--open { display: block; }
  .nav__list { flex-direction: column; }
  .nav__link { padding: .75rem 1rem; }
  .nav-toggle { display: flex; }
  .header__actions .btn--primary { display: none; }
  .stat__divider { display: none; }
  .stats-row { justify-content: center; gap: 2rem; }
}
@media (max-width:600px) {
  .science-grid { grid-template-columns: 1fr; }
  .why-now__stats { grid-template-columns: 1fr 1fr; }
  .hero__ctas { flex-direction: column; }
  .hero__ctas .btn { width: 100%; justify-content: center; }
  .process-step { grid-template-columns: 48px 1fr; gap: 1rem; }
  .process-connector { margin-left: 23px; }
}